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Anti-CRADD Polyclonal Antibody (ARO-A13871)

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概述
货号ARO-A13871
品牌ProteoGenix
描述
Anti-CRADD Polyclonal Antibody (ARO-A13871) is a rabbit polyclonal antibody detecting RAIDD, CRADD, RIP-associated protein with a death domain, Caspase and RIP adapter with death domain, Death domain-containing protein CRADD in ELISA, IHC, WB. Suitable for Human, Mouse, Pongo abelii.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Pongo abelii
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human CRADD (Met1-Leu140).
靶标RAIDD, CRADD, RIP-associated protein with a death domain, Caspase and RIP adapter with death domain, Death domain-containing protein CRADD
纯化方式Purified by antigen affinity column.
Accession号P78560
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Death domain-containing protein CRADD is a ~22 kDa protein. Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway.

1. Tinel, A. et al. (2004) Science (New York, N.Y.) 304, 843-6. PMID: 15073321
2. Vakifahmetoglu, H. et al. (2006) Oncogene 25, 5683-92. PMID: 16652156
3. Tinel, A. et al. (2007) The EMBO journal 26, 197-208. PMID: 17159900
4. Park, HH. et al. (2007) Cell 128, 533-46. PMID: 17289572
5. Ahmad, M. et al. (1997) Cancer research 57, 615-9. PMID: 9044836
6. Duan, H. et al. (1997) Nature 385, 86-9. PMID: 8985253
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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