

| 货号 | ARO-A13871 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
Anti-CRADD Polyclonal Antibody (ARO-A13871) is a rabbit polyclonal antibody detecting RAIDD, CRADD, RIP-associated protein with a death domain, Caspase and RIP adapter with death domain, Death domain-containing protein CRADD in ELISA, IHC, WB. Suitable for Human, Mouse, Pongo abelii.
Highlights
|
| 种属反应性 | Human, Mouse, Pongo abelii |
| 应用 | ELISA, IHC, WB |
| 宿主 | Rabbit |
| 同种型 | IgG |
| 克隆类型 | Polyclonal |
| 免疫原 | E. coli - derived recombinant Human CRADD (Met1-Leu140). |
| 靶标 | RAIDD, CRADD, RIP-associated protein with a death domain, Caspase and RIP adapter with death domain, Death domain-containing protein CRADD |
| 纯化方式 | Purified by antigen affinity column. |
| Accession号 | P78560 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Death domain-containing protein CRADD is a ~22 kDa protein. Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. 1. Tinel, A. et al. (2004) Science (New York, N.Y.) 304, 843-6. PMID: 15073321 2. Vakifahmetoglu, H. et al. (2006) Oncogene 25, 5683-92. PMID: 16652156 3. Tinel, A. et al. (2007) The EMBO journal 26, 197-208. PMID: 17159900 4. Park, HH. et al. (2007) Cell 128, 533-46. PMID: 17289572 5. Ahmad, M. et al. (1997) Cancer research 57, 615-9. PMID: 9044836 6. Duan, H. et al. (1997) Nature 385, 86-9. PMID: 8985253 |
| Note | For research use only. |

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