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Anti-MANF Polyclonal Antibody (ARO-A13911)

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概述
货号ARO-A13911
品牌ProteoGenix
描述
Anti-MANF Polyclonal Antibody (ARO-A13911) is a rabbit polyclonal antibody detecting ARP, ARMET, MANF, Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bos taurus.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat, Bos taurus
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human MANF (Gly28-Leu182).
靶标ARP, ARMET, MANF, Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET
纯化方式Purified by antigen affinity column.
Accession号P55145
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a ~20 kDa protein. Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions.

1. Petrova, P. et al. (2003) Journal of molecular neuroscience : MN 20, 173-88. PMID: 12794311
2. Apostolou, A. et al. (2008) Experimental cell research 314, 2454-67. PMID: 18561914
3. Glembotski, CC. et al. (2012) The Journal of biological chemistry 287, 25893-904. PMID: 22637475
4. Bai, M. et al. (2018) Nature communications 9, 897. PMID: 29497057
5. Kovaleva, V. et al. (2023) Cell reports 42, 112066. PMID: 36739529
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-MANF Polyclonal Antibody

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