Anti-MANF Polyclonal Antibody (HX175014)

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概述
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参考文献
产品说明书

概述

货号

HX175014

品牌

abinScience

描述

Anti-MANF Polyclonal Antibody (HX175014) is a rabbit polyclonal antibody detecting MANF in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human MANF (Gly28-Leu182).

靶标

ARP, ARMET, MANF, Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET

纯化方式

Purified by antigen affinity column.

Accession号

P55145

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a ~20 kDa protein. Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions.

1. Petrova, P. et al. (2003) Journal of molecular neuroscience : MN 20, 173-88. PMID: 12794311

2. Apostolou, A. et al. (2008) Experimental cell research 314, 2454-67. PMID: 18561914

3. Glembotski, CC. et al. (2012) The Journal of biological chemistry 287, 25893-904. PMID: 22637475

4. Bai, M. et al. (2018) Nature communications 9, 897. PMID: 29497057

5. Kovaleva, V. et al. (2023) Cell reports 42, 112066. PMID: 36739529

Note

For research use only.

图片

参考文献

产品说明书

Anti-MANF Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-MANF Polyclonal Antibody (HX175014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-MANF Polyclonal Antibody (HX175014)

概述

图片

参考文献

产品说明书

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