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Anti-TPMT Polyclonal Antibody (ARO-A13933)

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概述
货号ARO-A13933
品牌ProteoGenix
描述
Anti-TPMT Polyclonal Antibody (ARO-A13933) is a rabbit polyclonal antibody detecting Thiopurine methyltransferase, Thiopurine S-methyltransferase, TPMT in ELISA, IHC, WB. Suitable for Human, Chlorocebus aethiops, Gorilla gorilla gorilla, Pan troglodytes, Pongo pygmaeus.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Chlorocebus aethiops, Gorilla gorilla gorilla, Pan troglodytes, Pongo pygmaeus
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human TPMT (Leu26-His227).
靶标Thiopurine methyltransferase, Thiopurine S-methyltransferase, TPMT
纯化方式Purified by antigen affinity column.
Accession号P51580
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Thiopurine S-methyltransferase (TPMT) is a ~28 kDa protein. Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.

1. Peng, Y. et al. (2008) Biochemistry 47, 6216-25. PMID: 18484748
2. Weinshilboum, RM. et al. (1978) Clinica chimica acta; international journal of clinical chemistry 85, 323-33. PMID: 657528
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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