Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Malate dehydrogenase, cytoplasmic (MDH1) is a ~36 kDa protein. Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS).
1. Friedrich, CA. et al. (1987) Biochemical genetics 25, 657-69. PMID: 2449162
2. Friedrich, CA. et al. (1988) Annals of human genetics 52, 25-37. PMID: 3052244
3. Broeks, MH. et al. (2019) Human genetics 138, 1247-1257. PMID: 31538237
4. Zhang, JY. et al. (2021) Cell research 31, 980-997. PMID: 34012073
