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Anti-NFKBIA Polyclonal Antibody (ARO-A14043)

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概述
货号ARO-A14043
品牌ProteoGenix
描述
Anti-NFKBIA Polyclonal Antibody (ARO-A14043) is a rabbit polyclonal antibody detecting NFKBI, Major histocompatibility complex enhancer-binding protein MAD3, IkB-alpha, IkappaBalpha, I-kappa-B-alpha, IKBA, NF-kappa-B inhibitor alpha, NFKBIA, MAD3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Pig.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat, Pig
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human NFKBIA (Lys67-Glu302).
靶标NFKBI, Major histocompatibility complex enhancer-binding protein MAD3, IkB-alpha, IkappaBalpha, I-kappa-B-alpha, IKBA, NF-kappa-B inhibitor alpha, NFKBIA, MAD3
纯化方式Purified by antigen affinity column.
Accession号P25963
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

NF-kappa-B inhibitor alpha (NFKBIA) is a ~35 kDa protein. Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

1. Ganchi, PA. et al. (1992) Molecular biology of the cell 3, 1339-52. PMID: 1493333
2. Quan, J. et al. (2023) Journal of immunology (Baltimore, Md. : 1950) 210, 640-652. PMID: 36651806
3. Scherer, DC. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 11259-63. PMID: 7479976
4. Chen, Z. et al. (1995) Genes & development 9, 1586-97. PMID: 7628694
5. Traenckner, EB. et al. (1995) The EMBO journal 14, 2876-83. PMID: 7796813
6. Brown, K. et al. (1995) Science (New York, N.Y.) 267, 1485-8. PMID: 7878466
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-NFKBIA Polyclonal Antibody

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