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Anti-PTBP1 Polyclonal Antibody (ARO-A14039)

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概述
货号ARO-A14039
品牌ProteoGenix
描述
Anti-PTBP1 Polyclonal Antibody (ARO-A14039) is a rabbit polyclonal antibody detecting PTB, Polypyrimidine tract-binding protein 1, 57 kDa RNA-binding protein PPTB-1, PTBP1, Heterogeneous nuclear ribonucleoprotein I, hnRNP I in ELISA, IHC, WB. Suitable for Human, Mouse, Bos taurus, Rat, Pig.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Bos taurus, Rat, Pig
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human PTBP1 (Met1-Ile531).
靶标PTB, Polypyrimidine tract-binding protein 1, 57 kDa RNA-binding protein PPTB-1, PTBP1, Heterogeneous nuclear ribonucleoprotein I, hnRNP I
纯化方式Purified by antigen affinity column.
Accession号P26599
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Polypyrimidine tract-binding protein 1 (PTBP1) is a ~59 kDa protein. Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA.

1. Wang, J. et al. (2004) Journal of neurochemistry 88, 1078-90. PMID: 15009664
2. Zuccato, E. et al. (2004) The Journal of biological chemistry 279, 16980-8. PMID: 14966131
3. David, CJ. et al. (2010) Nature 463, 364-8. PMID: 20010808
4. Kafasla, P. et al. (2011) RNA (New York, N.Y.) 17, 1120-31. PMID: 21518806
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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