Anti-HMGB2 Polyclonal Antibody (ARO-A14038) is a rabbit polyclonal antibody detecting HMGB2, High mobility group protein 2, HMG-2, HMG2, High mobility group protein B2 in ELISA, IHC, WB. Suitable for Mouse, Bos taurus, Callithrix jacchus, Dog, Equus caballus, Chicken, Human, Macaca fascicularis, Papio anubis, Plecturocebus moloch, Rat, Pig.
Highlights
Affinity Purified — Minimal background and high purity for reliable results.
Multi-Application — Validated across multiple applications.
Multi-Species — Cross-reactive for translational research.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
High mobility group protein B2 (HMGB2) is a ~24 kDa protein. Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity.
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