Anti-HMGB2 Polyclonal Antibody (HB755014)

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100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HB755014

品牌

abinScience

描述

Anti-HMGB2 Polyclonal Antibody (HB755014) is a rabbit polyclonal antibody detecting HMGB2 in ELISA, IHC, WB. Suitable for Mouse, Bovine, Callithrix jacchus, Dog, and Equus caballus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human HMGB2 (Gly2-Pro187).

靶标

HMGB2, High mobility group protein 2, HMG-2, HMG2, High mobility group protein B2

纯化方式

Purified by antigen affinity column.

Accession号

P26583

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

High mobility group protein B2 (HMGB2) is a ~24 kDa protein. Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity.

1. Fan, Z. et al. (2002) Molecular and cellular biology 22, 2810-20. PMID: 11909973

2. Zimmerman, J. et al. (2008) Biochemical and biophysical research communications 371, 79-84. PMID: 18413230

3. Ugrinova, I. et al. (2009) Biochemistry 48, 6502-7. PMID: 19522541

4. Laurent, B. et al. (2010) Blood 115, 687-95. PMID: 19965638

5. Stros, M. (2010) Biochimica et biophysica acta 1799, 101-13. PMID: 20123072

6. Shykind, BM. et al. (1995) Genes & development 9, 1354-65. PMID: 7797075

7. Pusterla, T. et al. (2009) Autoimmunity 42, 308-10. PMID: 19811285

8. Küchler, R. et al. (2013) Antimicrobial agents and chemotherapy 57, 4782-93. PMID: 23877675

Note

For research use only.

图片

参考文献

产品说明书

Anti-HMGB2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HMGB2 Polyclonal Antibody (HB755014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HMGB2 Polyclonal Antibody (HB755014)

概述

图片

参考文献

产品说明书

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