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Anti-RB1 Polyclonal Antibody (ARO-A14211)

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概述
货号ARO-A14211
品牌ProteoGenix
描述
Anti-RB1 Polyclonal Antibody (ARO-A14211) is a rabbit polyclonal antibody detecting pRb, p110-RB1, Retinoblastoma-associated protein, Rb, p105-Rb, RB1, pp110 in ELISA, IHC, WB. Suitable for Mouse, Human, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Mouse, Human, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human RB1 (Gln639-Thr778).
靶标pRb, p110-RB1, Retinoblastoma-associated protein, Rb, p105-Rb, RB1, pp110
纯化方式Purified by antigen affinity column.
Accession号P06400
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Retinoblastoma-associated protein (RB1) is a ~106 kDa protein. Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C.

1. Harbour, JW. et al. (1999) Cell 98, 859-69. PMID: 10499802
2. Ren, S. et al. (2004) Cell 117, 239-51. PMID: 15084261
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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