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Anti-STAMBP Polyclonal Antibody (ARO-A14290)

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概述
货号ARO-A14290
品牌ProteoGenix
描述
Anti-STAMBP Polyclonal Antibody (ARO-A14290) is a rabbit polyclonal antibody detecting Endosome-associated ubiquitin isopeptidase, STAM-binding protein, AMSH, Associated molecule with the SH3 domain of STAM, STAMBP in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human STAMBP (Lys126-Ser368).
靶标Endosome-associated ubiquitin isopeptidase, STAM-binding protein, AMSH, Associated molecule with the SH3 domain of STAM, STAMBP
纯化方式Purified by antigen affinity column.
Accession号O95630
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

STAM-binding protein (STAMBP) is a ~48 kDa protein. Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes.

1. McCullough, J. et al. (2004) The Journal of cell biology 166, 487-92. PMID: 15314065
2. McDonell, LM. et al. (2013) Nature genetics 45, 556-62. PMID: 23542699
3. Guo, Y. et al. (2021) The Journal of biological chemistry 297, 101107. PMID: 34425109
4. Tanaka, N. et al. (1999) The Journal of biological chemistry 274, 19129-35. PMID: 10383417
5. Itoh, F. et al. (2001) The EMBO journal 20, 4132-42. PMID: 11483516
6. Ma, YM. et al. (2007) The Journal of biological chemistry 282, 9805-9812. PMID: 17261583
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-STAMBP Polyclonal Antibody

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