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Anti-AIFM1/AIF Polyclonal Antibody (ARO-A14285)

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概述
货号ARO-A14285
品牌ProteoGenix
描述
Anti-AIFM1/AIF Polyclonal Antibody (ARO-A14285) is a rabbit polyclonal antibody detecting AIFM1, AIF, Programmed cell death protein 8, PDCD8, Apoptosis-inducing factor 1, mitochondrial in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human AIFM1/AIF (Leu102-Asp613).
靶标AIFM1, AIF, Programmed cell death protein 8, PDCD8, Apoptosis-inducing factor 1, mitochondrial
纯化方式Purified by antigen affinity column.
Accession号O95831
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Apoptosis-inducing factor 1, mitochondrial (AIFM1/AIF) is a ~66 kDa protein. Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA.

1. Kim, JT. et al. (2006) FEBS letters 580, 6375-83. PMID: 17094969
2. Ghezzi, D. et al. (2010) American journal of human genetics 86, 639-49. PMID: 20362274
3. Rinaldi, C. et al. (2012) American journal of human genetics 91, 1095-102. PMID: 23217327
4. Mashimo, M. et al. (2021) The Journal of biological chemistry 296, 100046. PMID: 33168626
5. Sevrioukova, IF. (2016) Journal of molecular biology 428, 3650-65. PMID: 27178839
6. Son, YO. et al. (2009) Apoptosis : an international journal on programmed cell death 14, 796-808. PMID: 19418225
7. Hangen, E. et al. (2015) Molecular cell 58, 1001-14. PMID: 26004228
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-AIFM1/AIF Polyclonal Antibody

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