Anti-AIFM1/AIF Polyclonal Antibody (HF658014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HF658014

品牌

abinScience

描述

Anti-AIFM1/AIF Polyclonal Antibody (HF658014) is a rabbit polyclonal antibody detecting AIFM1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human AIFM1/AIF (Leu102-Asp613).

靶标

AIFM1, AIF, Programmed cell death protein 8, PDCD8, Apoptosis-inducing factor 1, mitochondrial

纯化方式

Purified by antigen affinity column.

Accession号

O95831

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Apoptosis-inducing factor 1, mitochondrial (AIFM1/AIF) is a ~66 kDa protein. Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA.

1. Kim, JT. et al. (2006) FEBS letters 580, 6375-83. PMID: 17094969

2. Ghezzi, D. et al. (2010) American journal of human genetics 86, 639-49. PMID: 20362274

3. Rinaldi, C. et al. (2012) American journal of human genetics 91, 1095-102. PMID: 23217327

4. Mashimo, M. et al. (2021) The Journal of biological chemistry 296, 100046. PMID: 33168626

5. Sevrioukova, IF. (2016) Journal of molecular biology 428, 3650-65. PMID: 27178839

6. Son, YO. et al. (2009) Apoptosis : an international journal on programmed cell death 14, 796-808. PMID: 19418225

7. Hangen, E. et al. (2015) Molecular cell 58, 1001-14. PMID: 26004228

Note

For research use only.

图片

参考文献

产品说明书

Anti-AIFM1/AIF Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-AIFM1/AIF Polyclonal Antibody (HF658014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-AIFM1/AIF Polyclonal Antibody (HF658014)

概述

图片

参考文献

产品说明书

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