Anti-Human CD93/C1qR Reference Antibody (Lexucitug, RUO) (HV345026)

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概述
图片
参考文献
产品说明书

概述

货号

HV345026

品牌

abinScience

描述

Research Grade lexucitug (HV345026) is a human monoclonal antibody. Suitable for Human.

种属反应性

Human

应用

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

宿主

Human

同种型

IgG1, kappa

克隆类型

Monoclonal

内毒素水平

< 10 EU/mg

纯度

>95% as determined by SDS-PAGE.

纯化方式

Protein A/G purified from cell culture supernatant.

Accession号

Q9NPY3

状态

Liquid

保存溶液

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Complement component C1q receptor (CD93/C1qR) is a ~68 kDa protein. Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration.

1. Geertsma, MF. et al. (1994) The American journal of physiology 267, L578-84. PMID: 7977768

2. Orlandini, M. et al. (2014) Oncotarget 5, 2750-60. PMID: 24809468

3. Galvagni, F. et al. (2016) Oncotarget 7, 10090-103. PMID: 26848865

4. Khan, KA. et al. (2017) Oncogene 36, 6097-6108. PMID: 28671670

5. Barbera, S. et al. (2023) International journal of biological macromolecules 224, 453-464. PMID: 36265539

6. Xu, Y. et al. (2024) Structure (London, England : 1993) 32, 282-291.e4. PMID: 38218180

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human CD93/C1qR Reference Antibody (Lexucitug, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD93/C1qR Reference Antibody (Lexucitug, RUO) (HV345026)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD93/C1qR Reference Antibody (Lexucitug, RUO) (HV345026)

概述

图片

参考文献

产品说明书

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