Anti-Human MORC3 Polyclonal Antibody (HD500014)

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规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HD500014

品牌

abinScience

描述

Anti-Human MORC3 Polyclonal Antibody (HD500014) is a rabbit polyclonal antibody detecting MORC3. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human MORC3 (Met1-Glu455).

靶标

KIAA0136, MORC family CW-type zinc finger protein 3, MORC3, NXP2, Nuclear matrix protein 2, ZCWCC3, Zinc finger CW-type coiled-coil domain protein 3

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q14149

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

MORC family CW-type zinc finger protein 3 (MORC3) is a ~107 kDa protein. Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity. Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3.

1. Sloan, E. et al. (2016) Journal of virology 90, 8621-33. PMID: 27440897

2. Gaidt, MM. et al. (2021) Nature 600, 138-142. PMID: 34759314

3. Takahashi, K. et al. (2007) Molecular biology of the cell 18, 1701-9. PMID: 17332504

4. Mimura, Y. et al. (2010) Journal of cell science 123, 2014-24. PMID: 20501696

5. Kimura, Y. et al. (2002) The Journal of biological chemistry 277, 20611-7. PMID: 11927593

6. Liu, Y. et al. (2016) The Journal of biological chemistry 291, 9000-13. PMID: 26933034

Note

For research use only

图片

参考文献

产品说明书

Anti-Human MORC3 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MORC3 Polyclonal Antibody (HD500014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MORC3 Polyclonal Antibody (HD500014)

概述

图片

参考文献

产品说明书

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