ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
KIAA0136, MORC family CW-type zinc finger protein 3, MORC3, NXP2, Nuclear matrix protein 2, ZCWCC3, Zinc finger CW-type coiled-coil domain protein 3
背景
MORC family CW-type zinc finger protein 3 is a ~107 kDa protein. Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity. Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3.
1. Sloan, E. et al. (2016) Journal of virology 90, 8621-33. PMID: 27440897
2. Gaidt, MM. et al. (2021) Nature 600, 138-142. PMID: 34759314
3. Takahashi, K. et al. (2007) Molecular biology of the cell 18, 1701-9. PMID: 17332504
4. Mimura, Y. et al. (2010) Journal of cell science 123, 2014-24. PMID: 20501696
5. Kimura, Y. et al. (2002) The Journal of biological chemistry 277, 20611-7. PMID: 11927593
6. Liu, Y. et al. (2016) The Journal of biological chemistry 291, 9000-13. PMID: 26933034
Note
For research use only
图片
SDS-PAGE
SDS-PAGE for Human MORC3 Recombinant Protein (N-His)
