Anti-Human TRIM28 Polyclonal Antibody (HC420034)

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50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HC420034

品牌

abinScience

描述

Anti-Human TRIM28 Polyclonal Antibody (HC420034) is a rabbit polyclonal antibody detecting TRIM28. Suitable for Mouse, Human, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human TRIM28 (Ser50-Gln243).

靶标

E3 SUMO-protein ligase TRIM28, EC:2.3.2.27, KAP-1, KAP1, KRAB-associated protein 1, KRAB-interacting protein 1, KRIP-1, Nuclear corepressor KAP-1, RING finger protein 96, RING-type E3 ubiquitin transferase TIF1-beta, RNF96, TIF1-beta, TIF1B, TRIM28, Transcription intermediary factor 1-beta, Tripartite motif-containing protein 28

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q13263

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Transcription intermediary factor 1-beta (TRIM28) is a ~88 kDa protein. Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1.

1. Huang, C. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 4470-3. PMID: 23543754

2. Serra, RW. et al. (2014) eLife 3, e02313. PMID: 24623306

3. Valle-García, D. et al. (2016) Epigenetics 11, 398-414. PMID: 27029610

Note

For research use only

图片

参考文献

产品说明书

Anti-Human TRIM28 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TRIM28 Polyclonal Antibody (HC420034)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TRIM28 Polyclonal Antibody (HC420034)

概述

图片

参考文献

产品说明书

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