Anti-Human TSHR Polyclonal Antibody (HB852014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HB852014

品牌

abinScience

描述

Anti-Human TSHR Polyclonal Antibody (HB852014) is a rabbit polyclonal antibody detecting TSHR. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human TSHR (Ser26-Ser278).

靶标

LGR3, TSH-R, TSHR, Thyroid-stimulating hormone receptor, Thyrotropin receptor

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P16473

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Thyrotropin receptor (TSHR) is a ~86 kDa protein. Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS).

1. Costagliola, S. et al. (2002) The EMBO journal 21, 504-13. PMID: 11847099

2. Nakabayashi, K. et al. (2002) The Journal of clinical investigation 109, 1445-52. PMID: 12045258

3. Faust, B. et al. (2022) Nature 609, 846-853. PMID: 35940205

4. Duan, J. et al. (2022) Nature 609, 854-859. PMID: 35940204

5. Morgan, SJ. et al. (2016) Thyroid : official journal of the American Thyroid Association 26, 1794-1803. PMID: 27638195

Note

For research use only

图片

参考文献

产品说明书

Anti-Human TSHR Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TSHR Polyclonal Antibody (HB852014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TSHR Polyclonal Antibody (HB852014)

概述

图片

参考文献

产品说明书

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