Anti-Human SLC6A4 Polyclonal Antibody (HB725014)

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规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HB725014

品牌

abinScience

描述

Anti-Human SLC6A4 Polyclonal Antibody (HB725014) is a rabbit polyclonal antibody detecting Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4; SLC6A4; HTT; SERT. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human SLC6A4 (Ala181-Ser252).

靶标

Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4; SLC6A4; HTT; SERT

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P31645

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Sodium-dependent serotonin transporter (SLC6A4) is a ~70 kDa protein. Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling. Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse.

1. Mortensen, OV. et al. (1999) Brain research. Molecular brain research 71, 120-6. PMID: 10407194

2. Kilic, F. et al. (2003) Molecular pharmacology 64, 440-6. PMID: 12869649

3. Henry, LK. et al. (2011) The Journal of biological chemistry 286, 30823-30836. PMID: 21730057

4. Coleman, JA. et al. (2016) Nature 532, 334-9. PMID: 27049939

5. Hasenhuetl, PS. et al. (2016) The Journal of biological chemistry 291, 25864-25876. PMID: 27756841

6. Yang, D. et al. (2021) Science advances 7, eabl3857. PMID: 34851672

7. Brenner, B. et al. (2007) Journal of neurochemistry 102, 206-15. PMID: 17506858

8. Carneiro, AM. et al. (2008) The Journal of clinical investigation 118, 1544-52. PMID: 18317590

Note

For research use only

图片

参考文献

产品说明书

Anti-Human SLC6A4 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SLC6A4 Polyclonal Antibody (HB725014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SLC6A4 Polyclonal Antibody (HB725014)

概述

图片

参考文献

产品说明书

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