Bulk Anti-Human C1QBP (60.11) Antibody (ICH1285-100mg)

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

This is clone 60.11, a mouse monoclonal antibody of the IgG1 kappa subclass raised against human C1QBP (complement component 1 Q subcomponent-binding protein; also known as gC1qR, p32, or HABP1; UniProt Q07021). Produced in a mouse host, it recognises the human protein and is validated for blocking applications, flow cytometry, immunohistochemistry, and Western blot. The antibody is offered as a low-endotoxin, bulk-format research reagent (mg to gram scale), making it suited to functional and cell-based studies that require large or consistent lots, including receptor-blocking, adhesion, and complement-pathway interrogation experiments. Because it is specific for the human target, it is oriented toward in-vitro human-cell work and ex-vivo assays rather than mouse in-vivo dosing models. Supplied for research use only (RUO); not for diagnostic or therapeutic use. The combination of a blocking-capable clone, low endotoxin content, and bulk availability supports reproducible functional assays across primary human cells, cell lines, and tissue sections. C1QBP (gC1qR / p32 / HABP1) is a highly acidic, multi-compartment protein encoded by the C1QBP gene. It is synthesised as a precursor, processed, and predominantly localised to the mitochondrial matrix, where it supports oxidative phosphorylation and mitochondrial protein synthesis; pools are also found at the cell surface, in the cytoplasm, and in the nucleus. The mature protein assembles into a doughnut-shaped homotrimer with an asymmetric charge distribution. Functionally, it binds the globular heads of C1q and influences the classical complement pathway, and it serves as a receptor or binding partner for hyaluronic acid, high-molecular-weight kininogen, and numerous host and pathogen ligands. Through these interactions it participates in inflammation, coagulation, cell adhesion, chemotaxis, and immune regulation. Surface-expressed C1QBP is frequently upregulated on tumour cells and has been studied in the context of cancer proliferation, metastasis, and the tumour microenvironment.