Bulk Anti-Human HLA Class I Heavy Chain (HC10) In Vivo Antibody - Low Endotoxin (ICH1306)

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概述

货号	ICH1306
品牌	IchorBio
描述	Bulk Anti-Human HLA Class I Heavy Chain (HC10) In Vivo Antibody - Low Endotoxin (ICH1306) is a CHO, clone HC10 (Mouse IgG2a kappa) antibody targeting HLA Class I Heavy Chain. Reactive with Mouse. Highlights ●Low Endotoxin — Suitable for in vivo and functional studies. ●High Purity — Minimal background for reliable results.
种属反应性	Mouse
宿主	CHO
克隆类型	Monoclonal
同种型	Mouse IgG2a kappa
克隆号	HC10
靶标	HLA Class I Heavy Chain
特异性	HLA-DR/DP/DQ
内毒素水平	<1 EU/mg
纯度	>95% as determined by SDS-PAGE.
纯化方式	This monoclonal antibody is selective for the unfolded/free heavy-chain form, making it a tool for studying MHC class I assembly and stress-related surface expression, plus blocking applications in humanised mouse research. HLA class I heavy chains normally assemble with beta-2-microglobulin and peptide before reaching the cell surface. Free heavy chains accumulate under cellular stress or altered antigen processing, and HC10 is a standard tool for probing this quality-control pathway.
Accession号	P10321
状态	Liquid
运输	Blue ice
稳定性和存储	Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –20°C or –80°C. Avoid Repeated Freeze Thaw Cycles.
规格	Size: 1mg
背景	This antibody is used as a pan-class-I reagent in humanised mouse, transplant and tumour immunology models, recognising HLA heavy chain independently of donor HLA type. HLA class I molecules present intracellular peptides to CD8+ T cells and act as ligands for NK cell inhibitory receptors, so their loss or downregulation underlies both graft rejection and tumour immune escape. Pan-reactive reagents like HC10 are valuable precisely because they work across HLA allotypes.
Note	For research use only
Isotype Control	ICH2259

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Bulk Anti-Human HLA Class I Heavy Chain (HC10) In Vivo Antibody - Low Endotoxin (ICH1306)

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Bulk Anti-Human HLA Class I Heavy Chain (HC10) In Vivo Antibody - Low Endotoxin (ICH1306)

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