Anti-HMGCR Polyclonal Antibody (HY041014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HY041014

品牌

abinScience

描述

Anti-HMGCR Polyclonal Antibody (HY041014) is a rabbit polyclonal antibody detecting HMGCR in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Cricetulus griseus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human HMGCR (Glu441-Asn875).

靶标

3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMGCR, HMG-CoA reductase

纯化方式

Purified by antigen affinity column.

Accession号

P04035

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) is a ~97 kDa protein. Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR is the main target of statins, a class of cholesterol-lowering drugs.

1. Cuccioloni, M. et al. (2011) Journal of lipid research 52, 897-907. PMID: 21357570

2. Luskey, KL. et al. (1985) The Journal of biological chemistry 260, 10271-7. PMID: 2991281

3. Yogev, Y. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2217831120. PMID: 36745799

4. Brown, MS. et al. (1980) Journal of lipid research 21, 505-17. PMID: 6995544

5. Istvan, ES. et al. (2001) Science (New York, N.Y.) 292, 1160-4. PMID: 11349148

6. Sarver, RW. et al. (2008) Journal of medicinal chemistry 51, 3804-13. PMID: 18540668

Note

For research use only.

图片

参考文献

产品说明书

Anti-HMGCR Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HMGCR Polyclonal Antibody (HY041014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HMGCR Polyclonal Antibody (HY041014)

概述

图片

参考文献

产品说明书

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