Anti-DES/Desmin Polyclonal Antibody (HB025014)

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50ug
100ug

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概述
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参考文献
产品说明书

概述

货号

HB025014

品牌

abinScience

描述

Anti-DES/Desmin Polyclonal Antibody (HB025014) is a rabbit polyclonal antibody detecting Desmin in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human DES/Desmin (Met1-Leu470).

靶标

Desmin, DES

纯化方式

Purified by antigen affinity column.

Accession号

P17661

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Desmin is a ~53 kDa protein. Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces.

1. Hnia, K. et al. (2015) Cell and tissue research 360, 591-608. PMID: 25358400

2. Brodehl, A. et al. (2013) Circulation. Cardiovascular genetics 6, 615-23. PMID: 24200904

3. Clemen, CS. et al. (2015) Acta neuropathologica 129, 297-315. PMID: 25394388

4. Brodehl, A. et al. (2016) Journal of molecular and cellular cardiology 91, 207-14. PMID: 26724190

Note

For research use only.

图片

参考文献

产品说明书

Anti-DES/Desmin Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-DES/Desmin Polyclonal Antibody (HB025014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-DES/Desmin Polyclonal Antibody (HB025014)

概述

图片

参考文献

产品说明书

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