Anti-BMP6 Polyclonal Antibody (HB857014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HB857014

品牌

abinScience

描述

Anti-BMP6 Polyclonal Antibody (HB857014) is a rabbit polyclonal antibody detecting BMP6 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human BMP6 (Ser375-His513).

靶标

VG-1-R, VG-1-related protein, Bone morphogenetic protein 6, VGR-1, BMP-6, VGR, BMP6

纯化方式

Purified by antigen affinity column.

Accession号

P22004

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Bone morphogenetic protein 6 (BMP6) is a ~57 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target.

1. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025

2. Daher, R. et al. (2016) Gastroenterology 150, 672-683.e4. PMID: 26582087

3. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509

4. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957

5. Saremba, S. et al. (2008) The FEBS journal 275, 172-83. PMID: 18070108

6. Pulkkinen, HH. et al. (2021) Angiogenesis 24, 129-144. PMID: 33021694

Note

For research use only.

图片

Western blot

Western blot analysis was performed using anti-BMP6 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse heart lysate

参考文献

产品说明书

Anti-BMP6 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-BMP6 Polyclonal Antibody (HB857014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-BMP6 Polyclonal Antibody (HB857014)

概述

图片

参考文献

产品说明书

相关产品推荐

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