Anti-Human alpha-Synuclein Polyclonal Antibody (HW755014)

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概述
图片
参考文献
产品说明书

概述

货号

HW755014

品牌

abinScience

描述

Anti-SNCA Polyclonal Antibody (HW755014) is a rabbit polyclonal antibody detecting SNCA in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Ateles geoffroyi, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human SNCA (Met1-Ala140).

靶标

Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA

纯化方式

Purified by antigen affinity column.

Accession号

P37840

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Alpha-synuclein (SNCA) is a ~14 kDa protein. Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging.

1. Burré, J. et al. (2010) Science (New York, N.Y.) 329, 1663-7. PMID: 20798282

2. Butler, B. et al. (2015) The Journal of biological chemistry 290, 29542-54. PMID: 26442590

3. Logan, T. et al. (2017) Nature neuroscience 20, 681-689. PMID: 28288128

4. Huang, CC. et al. (2018) Journal of cell science 131. PMID: 30404828

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human alpha-Synuclein Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human alpha-Synuclein Polyclonal Antibody (HW755014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human alpha-Synuclein Polyclonal Antibody (HW755014)

概述

图片

参考文献

产品说明书

相关产品推荐

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