Anti-Human alpha-Synuclein Reference Antibody (Lu AF82422, RUO) (HW755086)

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概述

货号	HW755086
品牌	abinScience
描述	Anti-Human SNCA/Alpha-synuclein (Lu AF82422) (HW755086) is a research-grade recombinant antibody targeting Alpha-synuclein. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG1
克隆号	Lu AF82422
表达系统	Mammalian cells
经测试应用	WB
靶标	Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P37840
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	LuAF82422
背景	Alpha-synuclein (SNCA) is a ~14 kDa protein. Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. 1. Burré, J. et al. (2010) Science (New York, N.Y.) 329, 1663-7. PMID: 20798282 2. Butler, B. et al. (2015) The Journal of biological chemistry 290, 29542-54. PMID: 26442590 3. Logan, T. et al. (2017) Nature neuroscience 20, 681-689. PMID: 28288128 4. Huang, CC. et al. (2018) Journal of cell science 131. PMID: 30404828
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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Western blot

Western blot analysis was performed using anti-SNCA monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human SNCA (Catalog No: HW755012)
Lane 2: negative control
SDS-PAGE

SDS-PAGE for Research Grade Anti-Human SNCA/Alpha-synuclein (Lu AF82422).
Bioactivity

Detects recombinant human SNCA (Catalog No: HW755012) in indirect ELISA

参考文献

产品说明书

Anti-Human alpha-Synuclein Reference Antibody (Lu AF82422, RUO).pdf

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质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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质量

浓度

体积

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公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

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Anti-Human alpha-Synuclein Reference Antibody (Lu AF82422, RUO) (HW755086)

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实验相关试剂

Anti-Human alpha-Synuclein Reference Antibody (Lu AF82422, RUO) (HW755086)

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产品说明书

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