



| 货号 | HW609107 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | FCM |
| 同种型 | IgG1, kappa |
| 克隆号 | SAA0130 |
| 靶标 | ADCYAP1R1, PACAP-R-1, PACAP type I receptor, Pituitary adenylate cyclase-activating polypeptide type I receptor, PACAP-R1 |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | P41586 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1) is a ~53 kDa protein. G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. 1. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270 2. Hu, E. et al. (2021) Journal of medicinal chemistry 64, 3427-3438. PMID: 33715378 3. Xu, Y. et al. (2022) Nature communications 13, 2272. PMID: 35477937 4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145 |
| Note | For research use only. |

Flow-cytometry using anti-human ADCYAD1R1 antibody. Human SH-SY5Y cell line were stained with an irrelevant antibody (Green Histogram) or an anti-human ADCYAD1R1 antibody monoclonal antibody (Catalog # HW609107 , Red Histogram) at a concentration of 20 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-human antibody (Catalog # HF690414) and cells analysed on a NovoCyte Flow Cytometer.

SDS-PAGE for Anti-Human ADCYAP1R1 Antibody (SAA0130)





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