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Anti-Human PAC1R Reference Antibody (Zelminemab, RUO) (HW609016)

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概述
货号HW609016
品牌abinScience
描述
Zelminemab (HW609016) is a research-grade recombinant antibody targeting ADCYAP1R1. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG1-kappa
表达系统Mammalian cells
靶标ADCYAP1R1, PACAP-R-1, PACAP type I receptor, Pituitary adenylate cyclase-activating polypeptide type I receptor, PACAP-R1
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P41586
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名AMG-301, 2225850-33-7
背景

Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1) is a ~53 kDa protein. G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine.

1. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270
2. Hu, E. et al. (2021) Journal of medicinal chemistry 64, 3427-3438. PMID: 33715378
3. Xu, Y. et al. (2022) Nature communications 13, 2272. PMID: 35477937
4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlAnti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)
图片

  • Bioactivity

    SEC-HPLC detection for Research Grade Zelminemab.

  • SDS-PAGE

    SDS-PAGE for Research Grade Zelminemab.

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human PAC1R Reference Antibody (Zelminemab, RUO)

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