

| 货号 | MY036307 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Mouse |
| 应用 | FCM, FuncS, ICC, IF, IHC, IHC-Fr |
| 同种型 | IgG2a, kappa |
| 克隆号 | 8D3 |
| 靶标 | Transferrin receptor protein 1, TfR1, T9, Trfr, p90, CD71, TFRC, TfR, sTfR, TR |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | Q62351 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Transferrin receptor protein 1 (CD71/TFRC) is a ~85 kDa protein. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Upon stimulation, positively regulates T and B cell proliferation through iron uptake. 1. Jabara, HH. et al. (2016) Nature genetics 48, 74-8. PMID: 26642240 2. Yang, J. et al. (2024) The Journal of clinical investigation 134. PMID: 38625739 |
| Note | For research use only. |

SDS-PAGE for Anti-Mouse CD71/TFRC Antibody (8D3)



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