Anti-Mouse Endosialin/CD248 Recombinant Antibody (G78) (MV681207)

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货号	MV681207
品牌	abinScience
种属反应性	Human, Mouse
应用	ELISA, FCM
同种型	IgG2a, lambda
克隆号	G78
经测试应用	FCM
靶标	Endosialin, TEM1, CD164L1, Tumor endothelial marker 1, CD248
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q91V98
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Endosialin (CD248) is a ~81 kDa protein. Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair. Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway. Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation. Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin. Also regulates LPS-induced inflammatory responses in macrophages by favoring production of proinflammatory cytokines. 1. Opavsky, R. et al. (2001) The Journal of biological chemistry 276, 38795-807. PMID: 11489895 2. Naylor, AJ. et al. (2014) PloS one 9, e107146. PMID: 25243742 3. Benedet, PO. et al. (2024) EBioMedicine 99, 104906. PMID: 38061240 4. Hong, YK. et al. (2019) The Journal of investigative dermatology 139, 2204-2214.e7. PMID: 30986375 5. Kapopara, PR. et al. (2021) Journal of thrombosis and haemostasis : JTH 19, 1932-1947. PMID: 33830628 6. Cheng, TL. et al. (2021) Translational research : the journal of laboratory and clinical medicine 232, 150-162. PMID: 33737161
Note	For research use only.

Flow Cytometry

Flow-cytometry using anti-mouse CD248 antibody.CD248 Transfected CHO cells were stained with an irrelevant antibody (Blue Histogram) or an anti-mouse CD248 antibody monoclonal antibody (Catalog # MV681207 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.

Dynamic molecular atlas of cardiac fibrosis at single-cell resolution shows CD248 in cardiac fibroblasts orchestrates interactions with immune cells.

产品说明书

Anti-Mouse Endosialin/CD248 Recombinant Antibody (G78).pdf

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Anti-Mouse Endosialin/CD248 Recombinant Antibody (G78) (MV681207)

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参考文献

产品说明书

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重组蛋白

抗体

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实验相关试剂

Anti-Mouse Endosialin/CD248 Recombinant Antibody (G78) (MV681207)

概述

图片

参考文献

产品说明书

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