Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3), PE (MB823127)

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货号	MB823127
品牌	abinScience
种属反应性	Mouse
应用	FCM
宿主	Rat
同种型	IgG1, kappa
克隆号	MAR1-5A3
偶联物	PE
克隆类型	Monoclonal
靶标	Interferon alpha/beta receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFN-R-1, IFNAR1, IFNAR, IFN-alpha/beta receptor 1, Type I interferon receptor 1
内毒素水平	Please contact with the lab for this information.
相关产品	Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), PE
Accession号	P33896
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Interferon alpha/beta receptor 1 (IFNAR1) is a ~65 kDa protein. Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. 1. Kumar, KG. et al. (2003) The EMBO journal 22, 5480-90. PMID: 14532120 2. Uzé, G. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 4774-8. PMID: 1533935 3. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985 4. de Weerd, NA. et al. (2013) Nature immunology 14, 901-7. PMID: 23872679
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3), PE.pdf

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Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3), PE (MB823127)

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图片

参考文献

产品说明书

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实验相关试剂

Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3), PE (MB823127)

概述

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参考文献

产品说明书

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