Anti-Human CYBB/NOX2 Recombinant Antibody (SAA0847) (HY448107)

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货号	HY448107
品牌	abinScience
种属反应性	Human
应用	FCM, IP, WB
同种型	IgG2a, kappa
克隆号	SAA0847
靶标	Cytochrome b558 subunit beta, Cytochrome b(558) subunit beta, Heme-binding membrane glycoprotein gp91phox, Neutrophil cytochrome b 91 kDa polypeptide, gp91-phox, NOX2, Cytochrome b-245 heavy chain, p22 phagocyte B-cytochrome, Superoxide-generating NADPH oxidase heavy chain subunit, gp91-1, NADPH oxidase 2, CYBB, CGD91-phox
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P04839
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	NADPH oxidase 2 (CYBB/NOX2) is a ~65 kDa protein. Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (Probable). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. NADPH oxidase complex assembly is impaired through interaction with NRROS. 1. Bionda, C. et al. (2004) Human genetics 115, 418-27. PMID: 15338276 2. Noreng, S. et al. (2022) Nature communications 13, 6079. PMID: 36241643 3. Liu, R. et al. (2022) eLife 11. PMID: 36413210 4. Liu, X. et al. (2024) Nature 627, 189-195. PMID: 38355798 5. Raad, H. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 1011-22. PMID: 19028840
Note	For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human CYBB/NOX2 Antibody (SAA0847)

产品说明书

Anti-Human CYBB/NOX2 Recombinant Antibody (SAA0847).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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Anti-Human CYBB/NOX2 Recombinant Antibody (SAA0847) (HY448107)

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参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CYBB/NOX2 Recombinant Antibody (SAA0847) (HY448107)

概述

图片

参考文献

产品说明书

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