Anti-Human CYBB/NOX2 Recombinant Antibody (SAA0847), APC (HY448137)

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货号	HY448137
品牌	abinScience
种属反应性	Human
应用	FCM, WB
宿主	Mouse
同种型	IgG2a, kappa
克隆号	SAA0847
偶联物	APC
克隆类型	Monoclonal
靶标	Cytochrome b558 subunit beta, Cytochrome b(558) subunit beta, Heme-binding membrane glycoprotein gp91phox, Neutrophil cytochrome b 91 kDa polypeptide, gp91-phox, NOX2, Cytochrome b-245 heavy chain, p22 phagocyte B-cytochrome, Superoxide-generating NADPH oxidase heavy chain subunit, gp91-1, NADPH oxidase 2, CYBB, CGD91-phox
内毒素水平	Please contact with the lab for this information.
相关产品	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC
Accession号	P04839
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	NADPH oxidase 2 (CYBB/NOX2) is a ~65 kDa protein. Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (Probable). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. NADPH oxidase complex assembly is impaired through interaction with NRROS. 1. Bionda, C. et al. (2004) Human genetics 115, 418-27. PMID: 15338276 2. Noreng, S. et al. (2022) Nature communications 13, 6079. PMID: 36241643 3. Liu, R. et al. (2022) eLife 11. PMID: 36413210 4. Liu, X. et al. (2024) Nature 627, 189-195. PMID: 38355798 5. Raad, H. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 1011-22. PMID: 19028840
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Human CYBB/NOX2 Recombinant Antibody (SAA0847), APC.pdf

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Anti-Human CYBB/NOX2 Recombinant Antibody (SAA0847), APC (HY448137)

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参考文献

产品说明书

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重组蛋白

抗体

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实验相关试剂

Anti-Human CYBB/NOX2 Recombinant Antibody (SAA0847), APC (HY448137)

概述

图片

参考文献

产品说明书

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