Anti-Human IFN-gamma Recombinant Antibody (SAA0414), FITC (HF813117)

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货号	HF813117
品牌	abinScience
种属反应性	Human
应用	ELISA, FCM
宿主	Mouse
同种型	IgG1, lambda
克隆号	SAA0414
偶联物	FITC
克隆类型	Monoclonal
靶标	Interferon gamma, IFN-gamma, Immune interferon, IFNG, IFN-γ
内毒素水平	Please contact with the lab for this information.
相关产品	Mouse IgG1 Recombinant Isotype Control Antibody (HyHEL-10), FITC
Accession号	P01579
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Interferon gamma (IFNG/IFN-gamma) is a ~19 kDa protein. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. 1. El Bougrini, J. et al. (2006) Cellular and molecular biology (Noisy-le-Grand, France) 52, 9-15. PMID: 16914093 2. Hisamatsu, H. et al. (1996) The Journal of experimental medicine 183, 1807-16. PMID: 8666937 3. Greenlund, AC. et al. (1993) The Journal of biological chemistry 268, 18103-10. PMID: 8349687 4. Akiyama, K. et al. (1994) FEBS letters 343, 85-8. PMID: 8163024 5. Fabunmi, RP. et al. (2001) Journal of cell science 114, 29-36. PMID: 11112687 6. Lah, TT. et al. (1995) FEBS letters 363, 85-9. PMID: 7729559
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Human IFN-gamma Recombinant Antibody (SAA0414), FITC.pdf

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Anti-Human IFN-gamma Recombinant Antibody (SAA0414), FITC (HF813117)

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Anti-Human IFN-gamma Recombinant Antibody (SAA0414), FITC (HF813117)

概述

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参考文献

产品说明书

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