Anti-Human IFN-gamma Reference Antibody (Emapalumab, RUO) (HF813016)

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概述

货号	HF813016
品牌	abinScience
描述	Emapalumab (HF813016) is a research-grade recombinant antibody targeting Interferon gamma. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG1-lambda
表达系统	Mammalian cells
经测试应用	WB
靶标	Interferon gamma, IFN-gamma, Immune interferon, IFNG
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P01579
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	NI-0501, emapalumab-lzsg, 1709815-23-5
背景	Interferon gamma (IFNG/IFN-gamma) is a ~19 kDa protein. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. 1. El Bougrini, J. et al. (2006) Cellular and molecular biology (Noisy-le-Grand, France) 52, 9-15. PMID: 16914093 2. Hisamatsu, H. et al. (1996) The Journal of experimental medicine 183, 1807-16. PMID: 8666937 3. Greenlund, AC. et al. (1993) The Journal of biological chemistry 268, 18103-10. PMID: 8349687 4. Akiyama, K. et al. (1994) FEBS letters 343, 85-8. PMID: 8163024 5. Fabunmi, RP. et al. (2001) Journal of cell science 114, 29-36. PMID: 11112687 6. Lah, TT. et al. (1995) FEBS letters 363, 85-9. PMID: 7729559
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)

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SDS-PAGE

SDS-PAGE for Research Grade Emapalumab.
Western blot

Western blot analysis was performed using anti-IFNG/IFN-gamma monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human IFNG/IFN-gamma (Catalog No: HF813012), 50ng
Lane 2: recombinant human IFNG/IFN-gamma (Catalog No: HF813012), 30ng
Lane 3: recombinant human IFNG/IFN-gamma (Catalog No: HF813012), 20ng

参考文献

产品说明书

Anti-Human IFN-gamma Reference Antibody (Emapalumab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

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公式

C₁ × V₁ = C₂ × V₂

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母液

C₁ (起始浓度)

V₁ (起始体积)

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V₂ (终体积)

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Anti-Human IFN-gamma Reference Antibody (Emapalumab, RUO) (HF813016)

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Anti-Human IFN-gamma Reference Antibody (Emapalumab, RUO) (HF813016)

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