| 货号 | HF813016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Human |
| 同种型 | IgG1-lambda |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | Interferon gamma, IFN-gamma, Immune interferon, IFNG |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | P01579 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | NI-0501, emapalumab-lzsg, 1709815-23-5 |
| 背景 | Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (Kd= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH). • Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation., PMID:33606996 • Dysregulation in IFN-γ signaling and response: the barricade to tumor immunotherapy., PMID:37275859 • IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption., PMID:31566580 • IFN-γ Contributes to the Immune Mechanisms of Hypertension., PMID:36591357 • Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop., PMID:33766856 • Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche., PMID:29950724 • IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies., PMID:34906138 • Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism., PMID:29787713 • Restraint of IFN-γ expression through a distal silencer CNS-28 for tissue homeostasis., PMID:37040761 • MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer., PMID:33495298 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
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