| 靶标 | CD29, FNRB, Fibronectin receptor subunit beta, GPIIA, Glycoprotein IIa, ITGB1, Integrin beta-1, MDF2, MSK12, VLA-4 subunit beta |
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| 背景 | Integrin beta-1 (CD29/ITGB1) is a ~88 kDa protein. Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. 1. Fujita, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 5809-19. PMID: 231254153. Saegusa, J. et al. (2008) The Journal of biological chemistry 283, 26107-15. PMID: 186355364. Fujita, M. et al. (2015) The Journal of biological chemistry 290, 259-71. PMID: 253988775. Bax, DV. et al. (2003) The Journal of biological chemistry 278, 34605-16. PMID: 128078876. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 171588818. Takada, YK. et al. (2017) The Journal of biological chemistry 292, 20067-20075. PMID: 290304309. Takada, YK. et al. (2019) Journal of immunology (Baltimore, Md. : 1950) 203, 1383-1391. PMID: 3133197310. Morris, GE. et al. (2022) British journal of pharmacology 179, 4958-4973. PMID: 35802072 |
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