Anti-Human CD66a/CEACAM1 Recombinant Antibody (SAA0761), FITC (HB880117)

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100T

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货号	HB880117
品牌	abinScience
种属反应性	Human
应用	ELISA, FCM
宿主	Mouse
同种型	IgG2a
克隆号	SAA0761
偶联物	FITC
克隆类型	Monoclonal
靶标	CD66a, BGP-1, Biliary glycoprotein 1, CEACAM1, Carcinoembryonic antigen-related cell adhesion molecule 1, BGP, BGP1
内毒素水平	Please contact with the lab for this information.
相关产品	Mouse IgG2a Recombinant Isotype Control Antibody (C1.18.4), FITC
Accession号	P13688
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Cell adhesion molecule CEACAM1 (CD66a) is a ~57 kDa protein. Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils. Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70. 1. Chen, Z. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 180, 6085-93. PMID: 18424730 2. Hosomi, S. et al. (2013) European journal of immunology 43, 2473-83. PMID: 23696226 3. Huang, YH. et al. (2015) Nature 517, 386-90. PMID: 25363763 4. Klaile, E. et al. (2005) Journal of cell science 118, 5513-24. PMID: 16291724
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Flow CytoMetry

Flow-cytometry using FITC anti-human CD66a antibody. HT-29 cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human CD66a monoclonal antibody (Catalog: HB880117, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

产品说明书

Anti-Human CD66a/CEACAM1 Recombinant Antibody (SAA0761), FITC.pdf

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Anti-Human CD66a/CEACAM1 Recombinant Antibody (SAA0761), FITC (HB880117)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD66a/CEACAM1 Recombinant Antibody (SAA0761), FITC (HB880117)

概述

图片

参考文献

产品说明书

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