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Anti-Human TP53/p53 (R175H mutant) Antibody (F2), FITC (ARO-A10862)

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概述
货号ARO-A10862
品牌ProteoGenix
描述
Anti-Human TP53/p53 (R175H mutant) Antibody (F2), FITC [F2] (ARO-A10862) is a mouse monoclonal antibody detecting Antigen NY-CO-13, Cellular tumor antigen p53, P53, Tumor suppressor p53, TP53, Phosphoprotein p53 in ELISA, FCM. Suitable for Human.
Highlights
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, FCM
宿主Mouse
同种型IgG2a, kappa
克隆号F2
偶联物FITC
克隆类型Monoclonal
靶标Antigen NY-CO-13, Cellular tumor antigen p53, P53, Tumor suppressor p53, TP53, Phosphoprotein p53
内毒素水平Please contact with the lab for this information.
Accession号P04637
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Store at 4°C for 12 months. Protect from light. Do not freeze.
背景

Cellular tumor antigen p53 (TP53) is a ~43 kDa protein. Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

1. Guo, A. et al. (2000) Nature cell biology 2, 730-6. PMID: 11025664
2. Bergamaschi, D. et al. (2003) Nature genetics 33, 162-7. PMID: 12524540
3. Louria-Hayon, I. et al. (2003) The Journal of biological chemistry 278, 33134-41. PMID: 12810724
4. An, W. et al. (2004) Cell 117, 735-48. PMID: 15186775
5. Ghosh, A. et al. (2004) Molecular and cellular biology 24, 7987-97. PMID: 15340061
6. Zhao, Y. et al. (2007) The Journal of biological chemistry 282, 11969-81. PMID: 17317671
7. Taira, N. et al. (2007) Molecular cell 25, 725-38. PMID: 17349958
8. Allton, K. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 11612-6. PMID: 19556538
9. Huarte, M. et al. (2010) Cell 142, 409-19. PMID: 20673990
10. Wu, L. et al. (2011) The Journal of biological chemistry 286, 2236-44. PMID: 20959462
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human TP53/p53 (R175H mutant) Antibody (F2), FITC

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