

| 货号 | MS826117 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human, Mouse |
| 应用 | ELISA, FCM |
| 宿主 | Rat |
| 同种型 | IgG1, kappa |
| 克隆号 | 6D7 |
| 偶联物 | FITC |
| 克隆类型 | Monoclonal |
| 靶标 | ShhNC, Sonic hedgehog protein, Shh N-terminal processed signaling domains, SHH, Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, ShhN, ShhNp, HHG-1 |
| 内毒素水平 | Please contact with the lab for this information. |
| 相关产品 | Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), FITC |
| Accession号 | Q62226 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Sonic hedgehog protein (SHH) is a ~47 kDa protein. The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN. Both activities occur in the reticulum endoplasmic. Once cleaved, ShhC is degraded in the endoplasmic reticulum. 1. Roelink, H. et al. (1995) Cell 81, 445-55. PMID: 7736596 2. Bumcrot, DA. et al. (1995) Molecular and cellular biology 15, 2294-303. PMID: 7891723 3. Porter, JA. et al. (1996) Science (New York, N.Y.) 274, 255-9. PMID: 8824192 4. Chen, X. et al. (2011) The Journal of cell biology 192, 825-38. PMID: 21357747 |
| Note | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |

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