Anti-Human CD49e/ITGA5 Recombinant Antibody (SAA0021), APC (HY464137)

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100T

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货号	HY464137
品牌	abinScience
种属反应性	Human
应用	FCM
宿主	Human
同种型	IgG4
克隆号	SAA0021
偶联物	APC
克隆类型	Monoclonal
靶标	CD49 antigen-like family member E, Integrin alpha-F, ITGA5, VLA-5, Fibronectin receptor subunit alpha, CD49e, Integrin alpha-5, FNRA
内毒素水平	Please contact with the lab for this information.
相关产品	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), APC
Accession号	P08648
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Integrin alpha-5 (CD49e/ITGA5) is a ~114 kDa protein. Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. 1. Saegusa, J. et al. (2008) The Journal of biological chemistry 283, 26107-15. PMID: 18635536 2. Fujita, M. et al. (2015) The Journal of biological chemistry 290, 259-71. PMID: 25398877 3. Bax, DV. et al. (2003) The Journal of biological chemistry 278, 34605-16. PMID: 12807887 4. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881 5. Schumacher, S. et al. (2021) Science advances 7. PMID: 33962943 6. Takada, YK. et al. (2017) The Journal of biological chemistry 292, 20067-20075. PMID: 29030430 7. Takada, YK. et al. (2019) Journal of immunology (Baltimore, Md. : 1950) 203, 1383-1391. PMID: 31331973
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Flow CytoMetry

Flow-cytometry using APC anti-human CD49e antibody. HUVEC cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD49e monoclonal antibody (Catalog: HY464137, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

产品说明书

Anti-Human CD49e/ITGA5 Recombinant Antibody (SAA0021), APC.pdf

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Anti-Human CD49e/ITGA5 Recombinant Antibody (SAA0021), APC (HY464137)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD49e/ITGA5 Recombinant Antibody (SAA0021), APC (HY464137)

概述

图片

参考文献

产品说明书

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