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Anti-Human alpha 5/CD49e Reference Antibody (Volociximab, RUO) (HY464016)

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概述
货号HY464016
品牌abinScience
描述
Volociximab (HY464016) is a research-grade recombinant antibody targeting CD49. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG4-nd
表达系统Mammalian cells
靶标CD49 antigen-like family member E, Integrin alpha-F, ITGA5, VLA-5, Fibronectin receptor subunit alpha, CD49e, Integrin alpha-5, FNRA
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P08648
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名558480-40-3
背景

Integrin alpha-5 (CD49e/ITGA5) is a ~114 kDa protein. Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1.

1. Saegusa, J. et al. (2008) The Journal of biological chemistry 283, 26107-15. PMID: 18635536
2. Fujita, M. et al. (2015) The Journal of biological chemistry 290, 259-71. PMID: 25398877
3. Bax, DV. et al. (2003) The Journal of biological chemistry 278, 34605-16. PMID: 12807887
4. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881
5. Schumacher, S. et al. (2021) Science advances 7. PMID: 33962943
6. Takada, YK. et al. (2017) The Journal of biological chemistry 292, 20067-20075. PMID: 29030430
7. Takada, YK. et al. (2019) Journal of immunology (Baltimore, Md. : 1950) 203, 1383-1391. PMID: 31331973
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)
图片

  • SDS-PAGE

    SDS-PAGE for Research Grade Volociximab.

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human alpha 5/CD49e Reference Antibody (Volociximab, RUO)

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