Anti-Human FOLR1 Recombinant Antibody (SAA0117), APC (HB825137)

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100T

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货号	HB825137
品牌	abinScience
种属反应性	Human
应用	FCM
宿主	Human
同种型	IgG1, kappa
克隆号	SAA0117
偶联物	APC
克隆类型	Monoclonal
经测试应用	FCM
靶标	Folate receptor alpha, FOLR, FOLR1, Adult folate-binding protein, Folate receptor 1, FR-alpha, KB cells FBP, FBP, Ovarian tumor-associated antigen MOv18, Folate receptor, adult
内毒素水平	Please contact with the lab for this information.
相关产品	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), APC
Accession号	P15328
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Folate receptor alpha (FOLR1) is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. FOLR1 is the therapeutic target of mirvetuximab soravtansine (Elahere). 1. Zhao, R. et al. (2009) The Journal of biological chemistry 284, 4267-74. PMID: 19074442 2. Chen, C. et al. (2013) Nature 500, 486-9. PMID: 23851396 3. Wibowo, AS. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 15180-8. PMID: 23934049 4. Lacey, SW. et al. (1989) The Journal of clinical investigation 84, 715-20. PMID: 2527252 5. Orr, RB. et al. (1994) Cancer research 54, 3905-11. PMID: 8033114 6. Rijnboutt, S. et al. (1996) The Journal of cell biology 132, 35-47. PMID: 8567728
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Flow CytoMetry

Flow-cytometry using APC anti-human FOLR1 antibody. Hela cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human FOLR1 monoclonal antibody (Catalog: HB825137, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.

产品说明书

Anti-Human FOLR1 Recombinant Antibody (SAA0117), APC.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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Anti-Human FOLR1 Recombinant Antibody (SAA0117), APC (HB825137)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human FOLR1 Recombinant Antibody (SAA0117), APC (HB825137)

概述

图片

参考文献

产品说明书

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