Anti-Human B7-1/CD80 Recombinant Antibody (IDEC-114), APC (HW630137)

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货号	HW630137
品牌	abinScience
种属反应性	Human
应用	FCM
宿主	Mouse
同种型	IgG1, lambda
克隆号	IDEC-114
偶联物	APC
克隆类型	Monoclonal
靶标	CD80, BB1, T-lymphocyte activation antigen CD80, CD28LG, B7, CD28LG1, LAB7, Activation B7-1 antigen, CTLA-4 counter-receptor B7.1
内毒素水平	Please contact with the lab for this information.
相关产品	Mouse IgG1 Recombinant Isotype Control Antibody (HyHEL-10), APC
Accession号	P33681
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	T-lymphocyte activation antigen CD80 (B7-1) is a ~33 kDa protein. Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. 1. Lu, B. et al. (2024) Acta pharmacologica Sinica 45, 1214-1223. PMID: 38467718 2. Collins, AV. et al. (2002) Immunity 17, 201-10. PMID: 12196291 3. Boulougouris, G. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1809-16. PMID: 10438913 4. Vandenborre, K. et al. (1999) Immunology 98, 413-21. PMID: 10583602 5. Stamper, CC. et al. (2001) Nature 410, 608-11. PMID: 11279502 6. Frauwirth, KA. et al. (2002) Immunity 16, 769-77. PMID: 12121659 7. Kennedy, A. et al. (2023) The EMBO journal 42, e111556. PMID: 36727298
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Human B7-1/CD80 Recombinant Antibody (IDEC-114), APC.pdf

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Anti-Human B7-1/CD80 Recombinant Antibody (IDEC-114), APC (HW630137)

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参考文献

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实验相关试剂

Anti-Human B7-1/CD80 Recombinant Antibody (IDEC-114), APC (HW630137)

概述

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参考文献

产品说明书

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