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Anti-Human B7-1/CD80 Reference Antibody (Galiximab, RUO) (HW630016)

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概述
货号HW630016
品牌abinScience
描述
Galiximab (HW630016) is a research-grade recombinant antibody targeting CD80. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG1-lambda
表达系统Mammalian cells
靶标CD80, BB1, T-lymphocyte activation antigen CD80, CD28LG, B7, CD28LG1, LAB7, Activation B7-1 antigen, CTLA-4 counter-receptor B7.1
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P33681
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名IDEC-114, 357613-77-5
背景

T-lymphocyte activation antigen CD80 (B7-1) is a ~33 kDa protein. Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway.

1. Lu, B. et al. (2024) Acta pharmacologica Sinica 45, 1214-1223. PMID: 38467718
2. Collins, AV. et al. (2002) Immunity 17, 201-10. PMID: 12196291
3. Boulougouris, G. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1809-16. PMID: 10438913
4. Vandenborre, K. et al. (1999) Immunology 98, 413-21. PMID: 10583602
5. Stamper, CC. et al. (2001) Nature 410, 608-11. PMID: 11279502
6. Frauwirth, KA. et al. (2002) Immunity 16, 769-77. PMID: 12121659
7. Kennedy, A. et al. (2023) The EMBO journal 42, e111556. PMID: 36727298
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)
图片

  • Bioactivity

    Detects Human CD80/B7-1 in indirect ELISAs.

  • SDS-PAGE

    SDS-PAGE for Research Grade Galiximab.

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human B7-1/CD80 Reference Antibody (Galiximab, RUO)

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