Anti-Human Notch-1 Recombinant Antibody (SAA0131), APC (HW570137)

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货号	HW570137
品牌	abinScience
种属反应性	Human
应用	FCM
宿主	Human
同种型	IgG2, lambda
克隆号	SAA0131
偶联物	APC
克隆类型	Monoclonal
靶标	hN1, TAN1, NEXT, NICD, Notch 1, Neurogenic locus notch homolog protein 1, Translocation-associated notch protein TAN-1, NOTCH1
内毒素水平	Please contact with the lab for this information.
相关产品	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10), APC
Accession号	P46531
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Neurogenic locus notch homolog protein 1 (NOTCH1) is a ~272 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus.
文献	1. NOTCH1 notch receptor 1 [Homo sapiens (human)] Gene ID: 4851, updated on 28-Oct-2019. [HW570137] 2. toyanova T, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6457-E6466. [HW570137]
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Human Notch-1 Recombinant Antibody (SAA0131), APC.pdf

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Anti-Human Notch-1 Recombinant Antibody (SAA0131), APC (HW570137)

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Anti-Human Notch-1 Recombinant Antibody (SAA0131), APC (HW570137)

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