Anti-Human Notch-1 Reference Antibody (MAb604.107, RUO) (HW570026)

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货号	HW570026
品牌	abinScience
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
同种型	IgG
克隆号	MAb604.107
生物活性	Notch 1 is shown to promote mouse luminal prostate cell survival and proliferation through the activation of the prosurvival NF-κB pathway [2]. Down-regulation of Notch 1 and Jagged1 in human prostate cancer cell lines decreases in vitro invasion and cell growth [2].
表达系统	Mammalian cells
克隆类型	Monoclonal
靶标	hN1, TAN1, NEXT, NICD, Notch 1, Neurogenic locus notch homolog protein 1, Translocation-associated notch protein TAN-1, NOTCH1
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P46531
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	MAb604.107
背景	Neurogenic locus notch homolog protein 1 (NOTCH1) is a ~272 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus.
文献	1. NOTCH1 notch receptor 1 [Homo sapiens (human)] Gene ID: 4851, updated on 28-Oct-2019. [HW570026] 2. toyanova T, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6457-E6466. [HW570026]
Note	For research use only. Not suitable for clinical or therapeutic use.

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human NOTCH1 (MAb604.107)

产品说明书

Anti-Human Notch-1 Reference Antibody (MAb604.107, RUO).pdf

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Anti-Human Notch-1 Reference Antibody (MAb604.107, RUO) (HW570026)

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Anti-Human Notch-1 Reference Antibody (MAb604.107, RUO) (HW570026)

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