Anti-Human Notch-2/Notch-3 Recombinant Antibody (SAA0143), PE (HC513127)

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货号	HC513127
品牌	abinScience
种属反应性	Human
应用	FCM
宿主	Human
同种型	IgG2, kappa
克隆号	SAA0143
偶联物	PE
克隆类型	Monoclonal
内毒素水平	Please contact with the lab for this information.
相关产品	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10), PE
Accession号	Q04721, Q9UM47
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Neurogenic locus notch homolog protein 2 (NOTCH2/NOTCH3) is a ~265 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. 1. Simpson, MA. et al. (2011) Nature genetics 43, 303-5. PMID: 21378985 2. Isidor, B. et al. (2011) Nature genetics 43, 306-8. PMID: 21378989 3. Fukushima, H. et al. (2017) Molecular cell 68, 645-658.e5. PMID: 29149593 4. Zhu, P. et al. (2015) Nature communications 6, 7122. PMID: 25985737
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Human Notch-2/Notch-3 Recombinant Antibody (SAA0143), PE.pdf

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Anti-Human Notch-2/Notch-3 Recombinant Antibody (SAA0143), PE (HC513127)

概述

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参考文献

产品说明书

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实验相关试剂

Anti-Human Notch-2/Notch-3 Recombinant Antibody (SAA0143), PE (HC513127)

概述

图片

参考文献

产品说明书

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