Anti-Mouse EGFR Recombinant Antibody (SAA2220) (MF004107)

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100ug
1mg

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货号	MF004107
品牌	abinScience
种属反应性	Mouse
应用	ELISA, FCM, IHC, WB
同种型	IgG
克隆号	SAA2220
靶标	Epidermal growth factor receptor, EC:2.7.10.1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1
内毒素水平	Please contact with the lab for this information.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q01279
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Epidermal growth factor receptor (EGFR/ERBB1) is a ~134 kDa protein. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. EGFR is the therapeutic target of cetuximab (Erbitux) and panitumumab (Vectibix). 1. Fazioli, F. et al. (1993) The EMBO journal 12, 3799-808. PMID: 8404850 2. Peng, SC. et al. (2010) Nucleic acids research 38, 7446-57. PMID: 20639532 3. Eagles, DA. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119. PMID: 35131940
Note	For research use only.

SDS-PAGE

SDS-PAGE for Anti-Mouse EGFR/ERBB1 Antibody (SAA2220)

产品说明书

Anti-Mouse EGFR Recombinant Antibody (SAA2220).pdf

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Anti-Mouse EGFR Recombinant Antibody (SAA2220) (MF004107)

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Anti-Mouse EGFR Recombinant Antibody (SAA2220) (MF004107)

概述

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参考文献

产品说明书

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