Anti-Mouse EGFR Recombinant Antibody (SAA2220), PE (MF004137)

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货号	MF004137
品牌	abinScience
种属反应性	Mouse
应用	ELISA, FCM, WB
宿主	Rabbit
同种型	IgG
克隆号	SAA2220
偶联物	PE
克隆类型	Monoclonal
靶标	HER1, Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, EGFR, ERBB1, ERBB,
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
相关产品	Rabbit IgG Recombinant Isotype Control Antibody (HyHEL-10), PE
纯化方式	Affinity chromatography.
Accession号	Q01279
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Epidermal growth factor receptor (EGFR/ERBB1) is a ~134 kDa protein. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. EGFR is the therapeutic target of cetuximab (Erbitux) and panitumumab (Vectibix). 1. Fazioli, F. et al. (1993) The EMBO journal 12, 3799-808. PMID: 8404850 2. Peng, SC. et al. (2010) Nucleic acids research 38, 7446-57. PMID: 20639532 3. Eagles, DA. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119. PMID: 35131940
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Mouse EGFR Recombinant Antibody (SAA2220), PE.pdf

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Anti-Mouse EGFR Recombinant Antibody (SAA2220), PE (MF004137)

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Anti-Mouse EGFR Recombinant Antibody (SAA2220), PE (MF004137)

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