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Cinpanemab ELISA Kit (DW755018)

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  • 96T
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概述
货号DW755018
品牌abinScience
描述
Cinpanemab ELISA Kit (DW755018) — Quantitative sandwich ELISA for Cinpanemab. Sample: Plasma, Serum. Range: 0.31-5 μg/mL. Sensitivity: 0.156 μg/ml.
Highlights
  • Sandwich Format — High specificity, reliable quantification.
  • High Sensitivity — Optimized for low-abundance target detection.
  • Ready-to-Use — Complete kit with pre-coated plates included.
样本类型Plasma, Serum
灵敏度0.156 μg/ml
检测范围0.31-5 μg/mL
Accession号P37840
应用ELISA
检测方法Colorimetric
实验类型Quantitative
回收率80-120%
运输2-8 ℃
稳定性和存储The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
规格

Cinpanemab

别名BIIB-054, 2094516-02-4
背景

Alpha-synuclein (Cinpanemab) is a ~14 kDa protein. Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging.

1. Burré, J. et al. (2010) Science (New York, N.Y.) 329, 1663-7. PMID: 20798282
2. Butler, B. et al. (2015) The Journal of biological chemistry 290, 29542-54. PMID: 26442590
3. Logan, T. et al. (2017) Nature neuroscience 20, 681-689. PMID: 28288128
4. Huang, CC. et al. (2018) Journal of cell science 131. PMID: 30404828
NoteFor Research Use Only.
图片
参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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